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What is a supermouse?...

What is a supermouse?

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RL Brinster and R Palmiter (1982) successfully created the first transgenic mouse by transferring the rat growth hormone gene into the fertilised mouse egg by microinjection. This act was carried out in vitro. Following the transfer, the fertilised egg was implanted into the uterus of a pseudopregnant mouse. The mouse gave birth to mice that were relatively larger in size, possibly due to an increased synthesis of growth hormone directed by the rat growth homone transgene. This mouse was called supermouse because of its abnormal growth.
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