In this disease, there occurs a failure of chloride ion transport mechanism in cell surface membrane of epithelial cells, Sweat of the patient contains very high level of `Na^(+)` and `Cl^(-)` ions. The disease is

Options

A. (a) thalassaemia
B. (b) Alzheimer's disease
C. (c) Gaucher's disease
D. (d) cystic fibrosis

Answer

D

Explanation

Cystic fibrosis (CF) is an abnormal recessive disorder or infants, children and young adults that is due to a recessive autosomal allele present on chromosome 7. The disease gets its name from the fibrous cysts that appear in the pancreas. It produces a defective glycoprotein. The defective glycoprotein causes formation of thick mucus in skin, lungs pancreas, liver and other secretory organs. Sweat of the patient contains very high level of `Na^(+)` and `Cl^(-)`. There is failure of chloride ion transport mechanism in cell surface membrane of epthelia cell. Accumulation of thick mucus in lungs results in obstruction of airways. There is recurrent pulmonary infection, mucus deposition in pancreas, maldigestion of food with highn fat content uin stools. Liver may undergo cirrhosis. The sweat of the sufferer is saltier.