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Assertion : Sickle-cell anaemia is an au...

Assertion : Sickle-cell anaemia is an autosome-linked recessive disorder that can be transmitted if both parents are heterozygous for the gene
Reason : In sickle-cell anaemia, haemoglobin molecule undergoes polymerisation under low oxygen tension causing the change in shape in RBC

A

A and R both are correct and R is correct explanation of A

B

A and R both are correct and R is not correct explanation of A

C

A is correct but R is incorrect

D

A and R both are incorrect

Text Solution

Verified by Experts

The correct Answer is:
B
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The disease sickle-cell anaemia is caused by the substitution of overset("(i)") "____" by overset("(ii)") "____" at the overset("(iii)") "____" position of overset("(iv)") "____" globin chain of haemoglobin molecule Which of the following correctly fills the blanks in the above statements ?

Match column I with colimn II and select the correct option from the given codes {:(,"Column I",,"Column II"),("A.","Autosomal recessive trait","(i)","Down's syndrome or monogolism"),("B.","Sex-linked recessive trait","(ii)","Phenylketonuria"),("C.",underset("to autosomal recessive trait")"Metabolic erorr lined","(iii)","Haemophilia"),("D.","Additional 22st chromosome anaemia","(iv)","Sickle cell"):}