What would be the side products formed with primary amine in the Hofmann bromamide degradation reaction?

Options

A. `Na_2CO_3 + NaBr`
B. `NaBr + H_2O + NaOH`
C. `NaBr + H_2O + Na_2CO_3`
D. `Br_2 + H_2O + Na_2CO_3`

Answer

**Step-by-Step Solution:**

1. **Understanding the Hofmann Bromamide Degradation Reaction**: The Hofmann bromamide degradation reaction involves the conversion of a primary amide into a primary amine. This reaction is carried out by treating the amide with bromine (Br2) in the presence of a strong base, typically sodium hydroxide (NaOH).

2. **Reaction Mechanism**: The primary amide reacts with bromine and sodium hydroxide, leading to the formation of an isocyanate intermediate. This intermediate then hydrolyzes to form the primary amine.

3. **Identifying the Main Products**: The main product of this reaction is the primary amine. For example, if we start with a primary amide like RCONH2, the product will be RNH2 (the corresponding primary amine).

4. **Identifying Side Products**: In addition to the primary amine, the reaction also produces side products. The side products formed during the Hofmann bromamide degradation reaction include:
- Sodium bromide (NaBr)
- Sodium carbonate (Na2CO3)
- Water (H2O)

5. **Conclusion**: Therefore, when a primary amine is formed from the Hofmann bromamide degradation reaction, the side products are sodium bromide, sodium carbonate, and water.

**Final Answer**: The side products formed with a primary amine in the Hofmann bromamide degradation reaction are sodium bromide (NaBr), sodium carbonate (Na2CO3), and water (H2O).

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