In prokaryotes, the negatively charged DNA is held with some positively charged proteins in a region called as:

Options

A. Nucleus
B. Nucleoid
C. Nucleolus
D. Nucleoli

Explanation

To solve the question regarding the region in prokaryotes where negatively charged DNA is held with positively charged proteins, we can follow these steps:

### Step-by-Step Solution:

1. **Understanding Prokaryotes**:
- Prokaryotes are unicellular organisms that lack a well-defined nucleus. Examples include bacteria like E. coli.
- They have a simpler cellular structure compared to eukaryotes.

**Hint**: Remember that prokaryotes do not have a true nucleus.

2. **Identifying the Genetic Material**:
- In prokaryotes, the genetic material is DNA, which is negatively charged due to its phosphate backbone.
- This DNA is not scattered throughout the cell but is organized in a specific region.

**Hint**: Think about how DNA is structured in prokaryotic cells compared to eukaryotic cells.

3. **Role of Proteins**:
- The negatively charged DNA interacts with positively charged proteins. This interaction helps in organizing the DNA within the cell.
- These proteins assist in the structural organization of the DNA.

**Hint**: Consider the charge interactions between DNA and proteins.

4. **Identifying the Region**:
- The specific region where the DNA is organized and held with proteins in prokaryotes is called the "nucleoid."
- The nucleoid is not a membrane-bound structure but rather a region in the cytoplasm where the DNA is concentrated.

**Hint**: Recall the term used to describe the area in prokaryotes that contains their genetic material.

5. **Choosing the Correct Answer**:
- The options provided are:
1. Nucleus
2. Nucleoid
3. Nucleus (repeated)
4. Nucleolide
- Since prokaryotes do not have a nucleus and the correct term for the region containing DNA is "nucleoid," the correct answer is option B: nucleoid.

**Hint**: Eliminate options that do not fit the characteristics of prokaryotic cells.

### Final Answer:
The region in prokaryotes where negatively charged DNA is held with positively charged proteins is called the **nucleoid**.