Which is the most appropriate stage to count the number of chromosomes?

Options

A. Prophase
B. Interphase
C. Metaphase
D. Telophase

Answer

To determine the most appropriate stage to count the number of chromosomes, we will analyze each stage of the cell cycle and identify where chromosomes are most visible and distinct.

### Step-by-Step Solution:

1. **Understanding Chromosome Structure**:
- Chromosomes are made of chromatin, which is a complex of DNA and proteins. During cell division, chromatin condenses to form distinct chromosomes that can be counted.

2. **Analyzing Prophase**:
- In prophase, chromatin condenses into visible chromosomes. However, they are not yet aligned, making it difficult to count them accurately. Therefore, while chromosomes are visible, this stage is not the best for counting.

3. **Analyzing Interphase**:
- Interphase is the phase where the cell is preparing for division. During this time, chromatin is in a less condensed form, making chromosomes not visible. Thus, counting chromosomes during interphase is not possible.

4. **Analyzing Metaphase**:
- Metaphase is the stage where chromosomes are aligned along the equatorial plane of the cell. At this point, chromosomes are fully condensed and clearly visible, making it the most appropriate stage for counting the number of chromosomes.

5. **Analyzing Telophase**:
- In telophase, the chromosomes have reached the poles of the cell and begin to de-condense back into chromatin. The nuclear membrane reappears, and the chromosomes are not easily distinguishable, making counting difficult.

6. **Conclusion**:
- Based on the analysis, the most appropriate stage to count the number of chromosomes is **Metaphase**.

### Final Answer:
The most appropriate stage to count the number of chromosomes is **Metaphase**.