Which of the following reaction is not the evidence for presence aldehyde:

Options

A. Reaction of glucose with hyroxylamine
B. Reaction of glucose with `Br_2` water
C. Reaction of glucose with HCN
D. Reaction of glucose with acetyle chloride

Explanation

To determine which reaction does not provide evidence for the presence of an aldehyde group in glucose, we will analyze each reaction mentioned in the video transcript step by step.

### Step 1: Understand the structure of glucose
Glucose has the following structure:
- It contains an aldehyde group (-CHO) at the first carbon atom.
- The general formula for glucose is C₆H₁₂O₆.

### Step 2: Analyze the reactions one by one

#### Reaction 1: Glucose with Hydroxylamine
- Hydroxylamine reacts with aldehydes to form oximes.
- The reaction can be represented as:
\[ \text{RCHO} + \text{NH}_2\text{OH} \rightarrow \text{RCH=NOH} + \text{H}_2\text{O} \]
- Since glucose contains an aldehyde group, this reaction confirms the presence of the aldehyde.

#### Reaction 2: Glucose with Bromine Water
- Bromine water is a mild oxidizing agent that reacts with aldehydes to produce carboxylic acids.
- The reaction can be represented as:
\[ \text{RCHO} + \text{Br}_2 + \text{H}_2\text{O} \rightarrow \text{RCOOH} + \text{HBr} \]
- This reaction also confirms the presence of the aldehyde group in glucose.

#### Reaction 3: Glucose with HCN (Hydrogen Cyanide)
- HCN reacts with aldehydes to form cyanohydrins.
- The reaction can be represented as:
\[ \text{RCHO} + \text{HCN} \rightarrow \text{RCH(OH)CN} \]
- This reaction indicates the presence of the aldehyde group in glucose.

#### Reaction 4: Glucose with Acetyl Chloride
- Acetyl chloride reacts with alcohols to form esters.
- The reaction can be represented as:
\[ \text{R-OH} + \text{CH}_3\text{COCl} \rightarrow \text{R-O-C(=O)CH}_3 + \text{HCl} \]
- In this case, the aldehyde group does not participate in the reaction. Instead, the hydroxyl groups (-OH) of glucose react with acetyl chloride to form acetyl derivatives.
- This reaction does not provide evidence for the presence of an aldehyde group.

### Conclusion
The reaction that does not provide evidence for the presence of an aldehyde group in glucose is the reaction with acetyl chloride.

### Final Answer
The correct option is: **Reaction of glucose with acetyl chloride.**

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