Explain in brief structure of Insulin.

Explanation

Structure of insulin : Human insulin is made up of 51 amino acids arranged in two polypeptide chains-chain A (21-amino acids) and chain B (30 amino.acids), which are linked together by disulphide linkages: In mammals, including humans, insulin is synthesised. as a pro-hormone like a pro-enzyme, which needs to be processed before it becomes fully mature and functional hormone) which contains an extra stretch called the c peptide. This c peptide is not present in the mature insulin and is removed during maturation into insulin.
The main challenge for the production of insulin in the laboratory using rDNA technique was getting insulin assembled into its mature form.