Osmolarity close to cortex is 300 mOsmol/L and 1200 mOsmol/L in the inner medulla, the gradient mainly caused by
Osmolarity close to cortex is 300 mOsmol/L and 1200 mOsmol/L in the inner medulla, the gradient mainly caused by
A
bicarbonates and glucose
B
glucose and amino acids
C
NaCl and urea
D
NaCl only
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The correct Answer is:
To solve the question regarding the osmolarity gradient between the cortex and inner medulla of the kidney, we can follow these steps:
### Step-by-Step Solution:
1. **Understand Osmolarity**:
- Osmolarity refers to the concentration of solutes in a solution. In this case, we are comparing the osmolarity in the kidney's cortex (300 mOsmol/L) and the inner medulla (1200 mOsmol/L).
2. **Identify the Regions**:
- The kidney is divided into different regions: the cortex, outer medulla, and inner medulla. The cortex has a lower osmolarity compared to the inner medulla.
3. **Recognize the Gradient**:
- The significant difference in osmolarity (from 300 to 1200 mOsmol/L) indicates a concentration gradient. This gradient is essential for the kidney's ability to concentrate urine.
4. **Determine the Causes of the Gradient**:
- The osmolarity gradient is primarily caused by the reabsorption of specific solutes. The key solutes involved in creating this gradient are sodium chloride (NaCl) and urea.
5. **Explain the Role of NaCl and Urea**:
- NaCl is actively reabsorbed in the nephron, particularly in the loop of Henle, which contributes to the high osmolarity in the inner medulla.
- Urea also plays a crucial role as it is reabsorbed and contributes to the osmotic gradient, enhancing the kidney's ability to concentrate urine.
6. **Conclude the Answer**:
- Therefore, the gradient from 300 mOsmol/L in the cortex to 1200 mOsmol/L in the inner medulla is mainly caused by the presence of NaCl and urea.
### Final Answer:
The gradient is mainly caused by **NaCl and urea**.
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