Which of the following is an autoimmune disorder leading to paralysis of skeletal muscle?

Options

A. Myasthenia gravis
B. Myotonic dystrophy
C. Tetany
D. Muscular dystrophy

Answer

To solve the question "Which of the following is an autoimmune disorder leading to paralysis of skeletal muscle?", we will analyze the options provided and identify the correct answer.

### Step-by-Step Solution:

1. **Understanding Autoimmune Disorders**:
- Autoimmune disorders occur when the immune system mistakenly attacks the body's own tissues. In the context of muscle paralysis, we need to find a condition where this occurs specifically affecting skeletal muscles.

2. **Evaluating the Options**:
- **Option A: Myasthenia Gravis**: This is a well-known autoimmune disorder. It affects the neuromuscular junction, where nerves communicate with muscles. In Myasthenia Gravis, antibodies block or destroy the receptors for acetylcholine, a neurotransmitter essential for muscle contraction. This leads to weakness and paralysis of skeletal muscles.
- **Option B: Titinopathy**: This is a condition related to mutations in the titin gene, which can lead to muscle weakness but is not primarily an autoimmune disorder.
- **Option C: Muscular Dystrophy**: This is a genetic disorder characterized by progressive degeneration of muscle fibers. It is not an autoimmune disorder.
- **Option D: Other Options**: If there are any other options provided, they should be evaluated similarly, but based on the common knowledge, Myasthenia Gravis is the most recognized autoimmune disorder leading to muscle paralysis.

3. **Conclusion**:
- Based on the analysis, the correct answer is **Option A: Myasthenia Gravis**. This condition leads to paralysis of skeletal muscles due to the autoimmune response affecting the neuromuscular junction.

### Final Answer:
**Option A: Myasthenia Gravis**

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