Gout disease in humans is due to

Options

A. Excessive production of uricase
B. Impaired catabolism of pyrimidines
C. Excessive excretion of uric acid
D. Excessive catabolism of purines

Answer

**Step-by-Step Solution:**

1. **Understanding Gout Disease**: Gout is a type of arthritis characterized by sudden, severe attacks of pain, redness, and swelling in the joints. It primarily affects the big toe but can occur in other joints as well.

2. **Cause of Gout**: The primary cause of gout is the accumulation of uric acid in the blood, which can form crystals in the joints, leading to inflammation and pain.

3. **Role of Purines**: Purines are nitrogenous compounds found in many foods and are broken down in the body to produce uric acid. An excessive breakdown of purines leads to an increased level of uric acid.

4. **Excessive Catabolism of Purines**: When the body catabolizes (breaks down) purines excessively, it results in a higher production of uric acid than the body can eliminate. This excess uric acid crystallizes in the joints, causing gout.

5. **Conclusion**: Therefore, gout disease in humans is primarily due to the excessive catabolism of purines, leading to increased levels of uric acid in the blood.

**Final Answer**: Gout disease in humans is due to excessive catabolism of purines.

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