Local hormone of the following is

Options

A. Somatostatin
B. ACTH
C. Thyrocalcitonin
D. Thyroxine

Answer

To determine the local hormone from the given options, we need to analyze each option based on the definition and characteristics of local hormones.

### Step-by-Step Solution:

1. **Understand Local Hormones**: Local hormones are substances that are released by cells and act on nearby cells (paracrine action) or on the same cell that released them (autocrine action). They typically have localized effects rather than systemic effects.

2. **Evaluate the Options**:
- **Option 1: Somatostatin**: This hormone is produced by various tissues, including the nervous and digestive systems. It regulates the function of other hormones and acts locally within the gastrointestinal tract. Therefore, somatostatin is a local hormone.

- **Option 2: ACTH (Adrenocorticotropic Hormone)**: This hormone stimulates the adrenal glands to produce cortisol. It acts on distant target cells and is considered a tropic hormone, which means it does not act locally. Thus, it is not a local hormone.

- **Option 3: Thyrocalcitonin (Calcitonin)**: This hormone is produced by the thyroid gland and helps regulate calcium levels in the blood. While it has important functions, it acts systemically rather than locally, so it is not classified as a local hormone.

- **Option 4: Thyroxin**: This is another hormone produced by the thyroid gland that regulates metabolism and has systemic effects on the body. It is not a local hormone.

3. **Conclusion**: Based on the analysis, the only hormone that acts locally is **Somatostatin**. Therefore, the correct answer is **Somatostatin**.

### Final Answer:
The local hormone among the options provided is **Somatostatin**.