Prophase is characterised by

Options

A. Condensation of chromosomal material
B. Centrioles move towards opposite poles of the cell
C. Initiation of assembly of mitotic spindle
D. All

Answer

### Step-by-Step Solution:

1. **Understanding Prophase**: Prophase is the first stage of mitosis, which is a type of cell division. During this phase, several key changes occur in the cell.

2. **Condensation of Chromosomal Material**: One of the primary characteristics of prophase is the condensation of chromatin into visible chromosomes. This means that the genetic material becomes tightly packed and organized, making the chromosomes visible under a microscope.

3. **Movement of Centrioles**: During prophase, the centrioles, which are structures involved in cell division, begin to move towards opposite poles of the cell. This movement is essential for the formation of the mitotic spindle.

4. **Formation of Mitotic Spindle**: The mitotic spindle is a structure made of microtubules that helps segregate chromosomes during cell division. The initiation of the assembly of the mitotic spindle starts in prophase as the spindle fibers emerge from the centrosomes.

5. **Disappearance of the Nucleolus**: Another characteristic of prophase is the disappearance of the nucleolus, which is a small structure within the nucleus responsible for ribosome production.

6. **Breakdown of the Nuclear Envelope**: During prophase, the nuclear envelope, which encloses the nucleus, begins to break down, allowing the spindle fibers to interact with the chromosomes.

### Conclusion:
In summary, prophase is characterized by:
- Condensation of chromosomal material
- Movement of centrioles towards opposite poles
- Initiation of assembly of the mitotic spindle
- Disappearance of the nucleolus
- Breakdown of the nuclear envelope