Maturation of RBC requires  

Options

A. Cynocobalamine and folic acid
B. Vitamin `B_12` & `B_6`
C. Vitamin biotin and folic acid
D. Pantotheric acid and folic acid

Answer

To answer the question regarding what is required for the maturation of red blood cells (RBCs), we can follow these steps:

### Step-by-Step Solution:

1. **Understand the Structure of Mature RBCs**:
- Mature red blood cells are biconcave disc-shaped and lack a nucleus and most organelles. This structure allows them to maximize space for hemoglobin, which is essential for oxygen transport.

2. **Identify the Nutritional Requirements for RBC Maturation**:
- The maturation of RBCs requires certain vitamins, specifically vitamin B12 (cyanocobalamin) and folic acid (vitamin B9). These vitamins are crucial for the proper development and maturation of red blood cells.

3. **Evaluate the Given Options**:
- The options provided include:
- Option 1: Cyanocobalamine and folic acid
- Option 2: Vitamin B12 and B6
- Option 3: Biotin and folic acid
- Option 4: Pantothenic acid and folic acid
- We need to analyze each option to determine which contains the correct vitamins necessary for RBC maturation.

4. **Analyze Each Option**:
- **Option 1**: Cyanocobalamine (B12) and folic acid (B9) - Both are essential for RBC maturation.
- **Option 2**: Vitamin B12 and B6 - While B12 is correct, B6 is not specifically required for RBC maturation.
- **Option 3**: Biotin and folic acid - Folic acid is correct, but biotin is not essential for RBC maturation.
- **Option 4**: Pantothenic acid and folic acid - Folic acid is correct, but pantothenic acid is not specifically required for RBC maturation.

5. **Conclusion**:
- The correct answer is **Option 1: Cyanocobalamine and folic acid**, as both are essential for the maturation of red blood cells.