Choose wrong combination with respect to the location of enzymes in `C_4` plants

Options

A. PEPcarboxylase - stroma of mesophyll cell chloroplast
B. RUBISCO - stroma of bundle sheath cell chloroplast
C. Malic enzyme - stroma of bundle sheath cell chloroplast
D. Pyruvate dikinase - stroma of mesophyll cell chloroplast

Answer

To solve the question regarding the wrong combination with respect to the location of enzymes in C4 plants, we will analyze each enzyme and its specified location step by step.

### Step-by-Step Solution:

1. **Identify the Enzymes and Their Locations:**
- **PEP Carboxylase**: The question states that PEP carboxylase is located in the stroma of mesophilic cells' chloroplasts.
- **Rubisco**: The question states that Rubisco is located in the stroma of bundle sheath cell chloroplasts.
- **Malic Enzyme**: The question states that the malic enzyme is located in the stroma of bundle sheath cell chloroplasts.
- **Pyruvate Dikinase**: The question states that pyruvate dikinase is located in the stroma of mesophilic cell chloroplasts.

2. **Evaluate Each Combination:**
- **PEP Carboxylase**: This enzyme is indeed found in the cytosol of mesophilic cells, not in the stroma of mesophilic cells' chloroplasts. Therefore, this statement is incorrect.
- **Rubisco**: This enzyme is correctly located in the stroma of bundle sheath cells' chloroplasts. This statement is correct.
- **Malic Enzyme**: This enzyme is also correctly located in the stroma of bundle sheath cells' chloroplasts. This statement is correct.
- **Pyruvate Dikinase**: This enzyme is located in both mesophilic and bundle sheath cells, but the question specifies only mesophilic cells. This statement is misleading but not entirely incorrect.

3. **Conclusion**: The wrong combination is the first one, which states that PEP carboxylase is located in the stroma of mesophilic cells' chloroplasts. The correct location is in the cytosol of mesophilic cells.

### Final Answer:
The wrong combination with respect to the location of enzymes in C4 plants is:
**PEP Carboxylase: Stroma of mesophilic cells chloroplast.**