Which of the following was first in born error of metabolism detected

Options

A. Alzheimer's disease
B. Albinism
C. Try-Sach's disease
D. Alkaptonuria

Answer

**Step-by-Step Solution:**

1. **Understanding the Question**: The question asks for the first inborn error of metabolism that was detected among the given options: Alzheimer's disease, albinism, trisomy disease, and alkaptonuria.

2. **Defining Inborn Errors of Metabolism**: Inborn errors of metabolism are genetic disorders caused by the absence or malfunction of an enzyme, leading to the accumulation of toxic substances in the body.

3. **Analyzing the Options**:
- **Alzheimer's Disease**: This is a progressive neurological disorder that affects memory and cognitive function, not an inborn error of metabolism.
- **Albinism**: This condition is characterized by a deficiency in melanin production, but it is not classified as an inborn error of metabolism.
- **Trisomy Disease**: This refers to chromosomal abnormalities (like Down syndrome) and is not an inborn error of metabolism.
- **Alkaptonuria**: This is a rare genetic metabolic disorder caused by the accumulation of homogentisic acid due to a deficiency in the enzyme needed to break it down.

4. **Identifying the Correct Answer**: Among the options, alkaptonuria is recognized as the first inborn error of metabolism that was detected.

5. **Conclusion**: Therefore, the correct answer to the question is **alkaptonuria**.

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