The chemical change in DNA molecule that could lead to synthesis of protein with an altered amino acid sequence is called.

Options

A. Replication
B. Lipid formation
C. Cellular membrane
D. Mutation

Answer

To solve the question regarding the chemical change in a DNA molecule that could lead to the synthesis of a protein with an altered amino acid sequence, we will analyze the options provided and determine the correct answer step by step.

### Step-by-Step Solution:

1. **Understanding the Question**: The question asks for a term that describes a chemical change in the DNA that results in a protein being synthesized with a different amino acid sequence. This indicates a change in the genetic information.

2. **Analyzing the Options**:
- **Option A: Replication**: This process involves making copies of DNA. It does not change the sequence of DNA but rather duplicates it. Therefore, this option is not correct.
- **Option B: Lipid Formation**: This refers to the synthesis of lipids, which are fats and oils. It does not relate to DNA or protein synthesis. Thus, this option is also incorrect.
- **Option C: Cellular Membrane**: This term refers to the structure that encloses the cell. It is not related to changes in DNA or protein synthesis, making this option incorrect as well.
- **Option D: Mutation**: This term refers to a change in the DNA sequence. Mutations can lead to changes in the amino acid sequence of proteins synthesized from that DNA. This aligns perfectly with the question.

3. **Conclusion**: After analyzing all the options, the correct answer is **D: Mutation**. A mutation in the DNA can result in a protein with an altered amino acid sequence.

### Final Answer:
The chemical change in a DNA molecule that could lead to the synthesis of a protein with an altered amino acid sequence is called **Mutation**.