Which of the following provide the sites for interaction of lymphocytes with the antigens ?
A)Bone marrow B) Spleen C) Thymus gland D) Lymph nodes E) Appendix F) Peyer's patches of small intestine

Options

A. B, C only
B. B, D, E, F
C. B, D only
D. B, D, F only

Answer

To determine which of the following options provide sites for interaction of lymphocytes with antigens, we need to analyze each option based on their functions related to lymphocyte activity.

### Step-by-Step Solution:

1. **Understanding Lymphocytes**:
- Lymphocytes are a type of white blood cell essential for the immune response. They include T cells and B cells, which are crucial for adaptive immunity.

2. **Identifying the Role of Each Option**:
- **A) Bone Marrow**:
- The bone marrow is primarily the site for the maturation of B cells. However, it does not serve as a site for the interaction of lymphocytes with antigens.
- **B) Spleen**:
- The spleen acts as a filter for blood and is a site where lymphocytes interact with antigens. It plays a significant role in the immune response by facilitating this interaction.
- **C) Thymus Gland**:
- The thymus gland is where T cells mature and are activated, but it does not facilitate direct interaction with antigens.
- **D) Lymph Nodes**:
- Lymph nodes are critical sites for antigen presentation and the activation of T and B cells, making them important for lymphocyte-antigen interaction.
- **E) Appendix**:
- The function of the appendix is not fully understood, but it is believed to play a role in storing good bacteria rather than directly interacting with lymphocytes and antigens.
- **F) Peyer's Patches of Small Intestine**:
- Peyer's patches are lymphoid tissues located in the ileum of the small intestine and are involved in the immune response, including interaction with antigens.

3. **Conclusion**:
- Based on the analysis, the sites that provide interaction of lymphocytes with antigens are:
- **B) Spleen**
- **D) Lymph Nodes**
- **F) Peyer's Patches**

Thus, the correct answer is **B, D, and F**.