The antibody dependent cytotoxicity is seen in

Options

A. local anaphylaxis
B. generalized anaphylaxis
C. immune complex reaction
D. non-compatible blood transfusion

Answer

**Step-by-Step Solution:**

1. **Understanding Antibody-Dependent Cytotoxicity (ADCC):**
- Antibody-dependent cytotoxicity refers to a mechanism through which immune cells can kill target cells that have been marked by antibodies. This process is crucial for the immune response against infected or cancerous cells.

2. **Analyzing the Options:**
- The question provides four options to choose from regarding where antibody-dependent cytotoxicity is seen.

3. **Option A: Local Anaphylaxis:**
- Local anaphylaxis is an immediate and temporary allergic response to an antigen. It does not involve cytotoxicity as it primarily affects local tissues and does not involve the killing of cells.

4. **Option B: General Anaphylaxis:**
- Generalized anaphylaxis is a severe allergic reaction that can be life-threatening. It involves systemic responses but is not directly related to antibody-dependent cytotoxicity.

5. **Option C: Immune Complex Reaction:**
- Immune complex reactions involve the formation of antigen-antibody complexes that can lead to tissue damage. However, this is more about inflammation and tissue damage rather than direct cytotoxicity.

6. **Option D: Non-Compatible Blood Transfusion:**
- Non-compatible blood transfusion occurs when the recipient's immune system produces antibodies against the donor's blood cells, leading to their destruction. This is a classic example of antibody-dependent cytotoxicity, where the antibodies mark the foreign cells for destruction by immune cells.

7. **Conclusion:**
- Based on the analysis, the correct answer to the question "The antibody-dependent cytotoxicity is seen in" is **Option D: Non-Compatible Blood Transfusion**.

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