The correct sequence of involvement of cell organelles in secretion of proteins from the cell is

Options

A. Nucleus `to` Ribosomes `to` Endoplasmic reticulum `to` Golgi apparatus `to` Secretory vesicles `to` Plasma membrane
B. Nucleus `to` Ribosomes `to` Endoplasmic reticulum `to` Lysosomes `to` Plasma membrane
C. Nucleus `to` Endoplasmic reticulum `to` Ribosomes `to` Golgi apparatus `to` Lysosomes `to` Plasma membrane
D. Nucleus `to` Endoplasmic reticulum `to` Ribosomes `to` Golgi apparatus `to` Secretory vesicles `to` Plasma membrane

Answer

To determine the correct sequence of involvement of cell organelles in the secretion of proteins from the cell, we can break down the process step by step:

### Step-by-Step Solution:

1. **Nucleus**: The process begins in the nucleus, where the genetic information (DNA) is transcribed into messenger RNA (mRNA). This mRNA carries the instructions for protein synthesis.

**Hint**: Remember that the nucleus is the control center of the cell, housing the DNA.

2. **Ribosomes**: The mRNA then exits the nucleus and travels to the ribosomes, which can be found free in the cytoplasm or attached to the endoplasmic reticulum (ER). Ribosomes are the sites where protein synthesis occurs, translating the mRNA into a polypeptide chain.

**Hint**: Think of ribosomes as the "factories" where proteins are assembled.

3. **Endoplasmic Reticulum (ER)**: After synthesis, the newly formed polypeptide chain enters the rough endoplasmic reticulum (RER), where it undergoes folding and modifications. The RER is called "rough" because it is studded with ribosomes.

**Hint**: The ER is like a conveyor belt that helps in processing and transporting proteins.

4. **Golgi Apparatus**: The proteins are then transported to the Golgi apparatus in vesicles. The Golgi apparatus further modifies, sorts, and packages the proteins for secretion or delivery to other organelles.

**Hint**: The Golgi apparatus is often referred to as the "post office" of the cell, where proteins are packaged and labeled for their final destination.

5. **Secretory Vesicles**: Once processed, the proteins are packaged into secretory vesicles that bud off from the Golgi apparatus. These vesicles transport the proteins to the plasma membrane.

**Hint**: Secretory vesicles are like delivery trucks that carry proteins to their final destination.

6. **Plasma Membrane**: Finally, the secretory vesicles fuse with the plasma membrane, releasing the proteins outside the cell through a process called exocytosis.

**Hint**: The plasma membrane acts as the gatekeeper, controlling what enters and exits the cell.

### Final Sequence:
The correct sequence of involvement of cell organelles in the secretion of proteins is:
1. Nucleus
2. Ribosomes
3. Endoplasmic Reticulum
4. Golgi Apparatus
5. Secretory Vesicles
6. Plasma Membrane

### Conclusion:
The correct answer to the question is the sequence: **Nucleus → Ribosomes → Endoplasmic Reticulum → Golgi Apparatus → Secretory Vesicles → Plasma Membrane**.