Phosophodiester bond is formed between

Options

A. `3^(1)` carbon and `5^(1)` carbon of sugar in a nucleotide
B. `5^(1)` carbon and `3^(1)` carbon of sugar in a nucleotide
C. `3^(1)` carbon of sugar of one nucleotide and `5^(1) - c` of of another nucleotide
D. All the above

Answer

To answer the question "Phosphodiester bond is formed between," we need to understand the structure of nucleotides and how they connect to form nucleic acids like DNA and RNA.

### Step-by-Step Solution:

1. **Understanding Nucleotides**:
- Nucleotides are the building blocks of nucleic acids. Each nucleotide consists of three components: a phosphate group, a sugar molecule (deoxyribose in DNA or ribose in RNA), and a nitrogenous base.

2. **Identifying the Components Involved in Phosphodiester Bonds**:
- The phosphodiester bond specifically involves the phosphate group of one nucleotide and the sugar (specifically the 3' carbon) of another nucleotide.

3. **Formation of Phosphodiester Bond**:
- The bond is formed between the 3' hydroxyl group of the sugar of one nucleotide and the phosphate group attached to the 5' carbon of the sugar of another nucleotide. This creates a linkage that forms the backbone of the nucleic acid.

4. **Analyzing the Options**:
- Option A: "3' carbon and 5' carbon of sugar in a nucleotide" - This is incorrect because it refers to the same nucleotide.
- Option B: "5' carbon and 3' carbon of sugar in a nucleotide" - This is also incorrect as it refers to the same nucleotide.
- Option C: "3' carbon of one nucleotide and 5' carbon of another nucleotide" - This is correct as it describes the actual formation of a phosphodiester bond between two different nucleotides.

5. **Conclusion**:
- Therefore, the correct answer is that a phosphodiester bond is formed between the 3' carbon of one nucleotide and the 5' carbon of another nucleotide.

### Final Answer:
The phosphodiester bond is formed between the 3' carbon of one nucleotide and the 5' carbon of another nucleotide.

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