The first clinical gene therapy includes introduction of gene into __________which codes for the enzyme __________

Options

A. defective lymphocytes, ADA
B. normal lymphocytes, adenyl cyclase
C. non functional lymphocytes, adenyl cyclase
D. 1 and 3

Answer

To answer the question regarding the first clinical gene therapy, we need to fill in the blanks with the appropriate terms based on the information provided.

### Step-by-Step Solution:

1. **Identify the Context**: The question asks about the first clinical gene therapy, which involves the introduction of a gene into a specific type of cell and the enzyme that this gene codes for.

2. **Recall Historical Context**: The first clinical gene therapy was conducted in 1990. It was performed on a four-year-old girl who had a genetic disorder.

3. **Identify the Disorder**: The disorder in question is known as Adenosine Deaminase Deficiency (ADA deficiency). This condition is linked to a deficiency in the immune system.

4. **Determine the Type of Cell**: The gene therapy involved the introduction of a gene into defective lymphocytes. Lymphocytes are a type of white blood cell that plays a crucial role in the immune response.

5. **Identify the Enzyme**: The gene that was introduced codes for the enzyme Adenosine Deaminase (ADA). This enzyme is essential for the proper functioning of the immune system.

6. **Fill in the Blanks**:
- The first clinical gene therapy includes the introduction of a gene into **defective lymphocytes** which codes for the enzyme **Adenosine Deaminase (ADA)**.

### Final Answer:
The first clinical gene therapy includes the introduction of gene into **defective lymphocytes** which codes for the enzyme **Adenosine Deaminase (ADA)**.

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