In a codon, wobbling is generally restricted to

Options

A. first N base
B. third N base
C. second N base
D. any base

Answer

To solve the question "In a codon, wobbling is generally restricted to," we can follow these steps:

### Step-by-Step Solution:

1. **Understanding Codons**: A codon is a sequence of three nucleotides on mRNA that corresponds to a specific amino acid or stop signal during protein synthesis.

2. **Defining Wobbling**: Wobbling refers to the flexibility in base pairing between the third base of a codon and the first base of its corresponding anticodon on tRNA. This concept was introduced by Francis Crick to explain how certain tRNA molecules can recognize multiple codons that code for the same amino acid.

3. **Codon Degeneracy**: Codon degeneracy means that multiple codons can code for the same amino acid. This is particularly evident in the genetic code where the third nucleotide in a codon often does not have strict pairing rules.

4. **Identifying the Position of Wobbling**: In the context of wobbling, it is primarily the third nucleotide of the codon that exhibits this flexibility. The first and second nucleotides generally follow strict base pairing rules.

5. **Conclusion**: Based on the explanation of wobbling and its relation to codons, we conclude that wobbling is generally restricted to the third nucleotide base of a codon.

### Final Answer:
Wobbling in a codon is generally restricted to the **third nucleotide base**.

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