What is the role of topoisomerases in eukaryotic DNA replication?

Options

A. Topoisomerase enzymes cut uncoil and reseal the double stranded DNA
B. Topoisomerase enzymes bind to the origin of replication sites within double stranded DNA
C. Topioisomerase enzymes open up the double stranded DNA at the replication fork.
D. Topoisomerase enzymes join the okazaki fragments together with phosphodiester bonds.

Answer

A