Which of the following is a suitable vector for the process of cloning in Human Genome Project (HGP) ?

Options

A. PAC (Protozoa Artificial Chromosomes)
B. FAC (Fungal Artificial Chromosomes0
C. VAC (Viral Artificial Chromosomes )
D. YAC (Yeast Artificial Chromosomes)

Answer

To determine a suitable vector for the process of cloning in the Human Genome Project (HGP), we need to consider the types of vectors that were utilized during the project.

### Step-by-Step Solution:

1. **Understand the Concept of Cloning Vectors**: Cloning vectors are DNA molecules used to transport foreign genetic material into a host cell. They are essential for cloning genes and studying their functions.

2. **Identify Common Cloning Vectors**: The most commonly used vectors in genetic engineering include plasmids, bacteriophages, bacterial artificial chromosomes (BACs), and yeast artificial chromosomes (YACs).

3. **Focus on the Human Genome Project**: The HGP aimed to map and understand all the genes of the human genome. For this purpose, specific vectors were employed to clone and analyze human DNA.

4. **Recognize the Vectors Used in HGP**: The two primary vectors used in the HGP were:
- **BAC (Bacterial Artificial Chromosome)**: Useful for cloning large fragments of DNA.
- **YAC (Yeast Artificial Chromosome)**: Also capable of carrying large DNA inserts and useful for eukaryotic DNA.

5. **Analyze the Given Options**: The question provides options including BAC and YAC. Since the question specifies that BAC is not listed, we focus on YAC.

6. **Select the Correct Answer**: Based on the information, the suitable vector for cloning in the HGP from the provided options is **YAC (Yeast Artificial Chromosome)**.

### Final Answer:
The suitable vector for the process of cloning in the Human Genome Project is **Option D: Yeast Artificial Chromosome (YAC)**.

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