Which of the following does not respond to Friedel Craft reaction

Options

A.
B.
C.
D.

Explanation

To determine which compound does not respond to Friedel-Crafts reactions, we need to understand the nature of these reactions and how certain functional groups affect the reactivity of aromatic compounds.

### Step-by-Step Solution:

1. **Understand Friedel-Crafts Reactions**:
Friedel-Crafts reactions are electrophilic aromatic substitution reactions that involve the introduction of an alkyl or acyl group into an aromatic ring. They typically require a Lewis acid catalyst (like AlCl3) to generate a strong electrophile.

2. **Identify the Compounds**:
The question implies that there are several compounds to consider. Common examples include benzene, toluene, aniline, and others. We need to analyze their structures and functional groups.

3. **Analyze Aniline**:
Aniline (C6H5NH2) has an amino group (-NH2) attached to the benzene ring. The nitrogen in the amino group has a lone pair of electrons that can donate to Lewis acids.

4. **Effect of the Amino Group**:
When aniline is treated with a Lewis acid in a Friedel-Crafts reaction, the lone pair on the nitrogen can coordinate with the Lewis acid, effectively deactivating the aromatic ring towards electrophilic substitution. This means that aniline does not readily undergo Friedel-Crafts reactions.

5. **Conclusion**:
Among the compounds typically considered in Friedel-Crafts reactions, aniline is the one that does not respond to these reactions due to the donation of its lone pair to the Lewis acid, preventing the formation of the necessary electrophile.

### Final Answer:
**Aniline does not respond to Friedel-Crafts reactions.**

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