Which of the following statement is not correct

Options

A. Goblet cells are present in the mucosa of intestine and secrete mucus
B. Oxyntic cells are present in the mucosa of stomach and secrete HCl
C. Acini is present in the pancreas and secretes carboxypeptidase
D. Brunner's glands are present in the submucosa of stomach and secrete pepsinogen

Explanation

To determine which statement is not correct, we will evaluate each statement one by one.

1. **Statement 1**: "Goblet cells are present in the mucosa of the intestine and secrete mucus."
- **Evaluation**: This statement is correct. Goblet cells are indeed found in the intestinal mucosa, and their primary function is to secrete mucus, which helps in lubrication and protection of the intestinal lining.

2. **Statement 2**: "Oxantic cells are present in the mucosa of the stomach and secrete HCl."
- **Evaluation**: This statement is also correct. Oxantic cells (more commonly known as parietal cells) are located in the gastric glands of the stomach mucosa and are responsible for secreting hydrochloric acid (HCl) as well as intrinsic factor.

3. **Statement 3**: "Acini are present in the pancreas and secrete carboxypeptidase."
- **Evaluation**: This statement is correct as well. The acinar cells in the pancreas produce and secrete digestive enzymes, including carboxypeptidase, which is involved in protein digestion.

4. **Statement 4**: "Brunner's glands are present in the submucosa of the stomach and secrete pepsinogen."
- **Evaluation**: This statement is incorrect. Brunner's glands are actually located in the submucosa of the duodenum (the first part of the small intestine), not the stomach. They secrete alkaline mucus to protect the intestinal lining from the acidic chyme coming from the stomach. Pepsinogen is secreted by the chief cells in the gastric glands of the stomach, not by Brunner's glands.

**Conclusion**: The statement that is not correct is the fourth one regarding Brunner's glands.