Tay Sachs disease is caused by deficiency in

Options

A. Hexosaminidase
B. Glucocerebrosidase
C. Galactocerebrosidase
D. Ceramidase

Explanation

**Step-by-Step Solution:**

1. **Understanding Tay-Sachs Disease**: Tay-Sachs disease is a genetic disorder that affects the nervous system. It is important to know that it is caused by a deficiency in a specific enzyme.

2. **Identifying the Enzyme**: The enzyme that is deficient in Tay-Sachs disease is called Hexosaminidase A (Hex-A). This enzyme is crucial for the breakdown of certain lipids in the body.

3. **Consequences of Enzyme Deficiency**: Due to the deficiency of Hexosaminidase A, a fatty substance known as GM2 ganglioside accumulates in the brain. This accumulation occurs because the body cannot properly break down GM2 ganglioside without the enzyme.

4. **Impact on the Nervous System**: The buildup of GM2 ganglioside leads to the destruction of nerve cells in the brain. This results in the neurological symptoms associated with Tay-Sachs disease, such as developmental delays, loss of motor skills, and other severe neurological impairments.

5. **Conclusion**: Therefore, Tay-Sachs disease is caused by a deficiency in Hexosaminidase A (Hex-A). The correct answer to the question is that Tay-Sachs disease is caused by the deficiency of Hexosaminidase A.