C-peptide of human insulin is

Options

A. A part of mature insulin molecule
B. Responsible for formation of disulphide bridges
C. Removed during maturation of proinsulin to insulin
D. Responsible for its biological activity

Answer

C

Explanation

The insulin in mammals is synthesised from a preprohormone called preproinsulin. This prohormone is relatively inactive. Preproinsulin is the primary translation production of the insulin gene having 110 amino acids with a signal peptide and an extra stretch called the C peptide. Removal C peptide converts proinsulin into insulin.