With regard to insulin choose correct option. (a) C-peptide is not present in mature insulin (b) The insulin produced by rDNA technology had C-peptide (c)The pro-insulin has C-peptide (d) A-peptide and B-peptide of insulin are interconnected by disulphide bridges

Options

A. (B) and (C) only
B. (A), (C) and (D) only
C. (A) and (D) only
D. (B) and (D) only

Answer

B

Explanation

• Insulin is synthesized as a pro-hormone which contains A-chain, B-chain and an extra stretch called the C-peptide.
• C-peptide present in pro-insulin is removed during its maturation. C-peptide is not present in mature insulin called humulin.
• The insulin produced by rDNA technology has only A-peptide and B-peptide.