Cushing's syndrome which is characterised by wasting of limb muscles and accumulation of fat in the trunk region is due to hypersecretion of

Options

A. Corticosteroid
B. Adrenalin
C. Progesterone
D. Adrenocorticotropin

Explanation

**Step-by-Step Solution:**

1. **Understanding Cushing's Syndrome**: Cushing's syndrome is a condition characterized by specific symptoms including the wasting of limb muscles and the accumulation of fat in the trunk region.

2. **Identifying the Cause**: The primary cause of Cushing's syndrome is the hypersecretion of certain hormones. It is essential to identify which hormone is responsible for these symptoms.

3. **Hormones to Consider**: The options provided are:
- Corticosteroid
- Adrenaline
- Progesterone
- Adenocorticotropic hormone (ACTH)

4. **Analyzing Each Hormone**:
- **Corticosteroids**: These are hormones produced by the adrenal glands, with cortisol being the main one. Excess cortisol leads to symptoms of Cushing's syndrome.
- **Adrenaline**: This hormone is also produced by the adrenal glands but is primarily involved in the fight-or-flight response and does not cause the symptoms associated with Cushing's syndrome.
- **Progesterone**: This hormone is involved in reproductive functions and does not relate to Cushing's syndrome.
- **Adenocorticotropic hormone (ACTH)**: This hormone stimulates the adrenal glands to produce cortisol. While it plays a role in the regulation of cortisol, it is not the hormone that is hypersecreted in Cushing's syndrome.

5. **Conclusion**: The hypersecretion of cortisol (a type of corticosteroid) is what leads to the symptoms of Cushing's syndrome. Therefore, the correct answer is **Corticosteroid**.

6. **Final Answer**: The hypersecretion of **Corticosteroid** is responsible for Cushing's syndrome.

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