Which one of the following pairs is mismatched

Options

A. Hyperthyroidism – exophthalmic goitre
B. Hypercortisolism – cretinism
C. Hypothyroidism – myxoedema
D. Hypercortisolism – cushing’s syndrome

Explanation

To determine which pair is mismatched, we will analyze each option provided in the question.

1. **Hyperthyroidism and Exophthalmic Goiter**:
- Hyperthyroidism is characterized by an overproduction of thyroid hormones. One of the conditions associated with hyperthyroidism is exophthalmic goiter, which is the protrusion of the eyes due to swelling of the tissues behind the eyes. This pair is correctly matched.

2. **Hypercortisolism and Cretinism**:
- Hypercortisolism refers to an excess of cortisol in the body, often leading to Cushing syndrome. Cretinism, on the other hand, is a condition caused by a deficiency of thyroid hormones, particularly in infants, leading to stunted physical and mental growth. Therefore, this pair is mismatched.

3. **Hypothyroidism and Myxedema**:
- Hypothyroidism is the condition resulting from insufficient thyroid hormone production. Myxedema is a severe form of hypothyroidism that occurs in adults, characterized by swelling of the skin and underlying tissues. This pair is correctly matched.

4. **Hypercortisolism and Cushing Syndrome**:
- As previously mentioned, hypercortisolism leads to Cushing syndrome, which is characterized by symptoms such as obesity, rounded face, and high blood pressure. This pair is correctly matched.

Based on the analysis, the mismatched pair is **Hypercortisolism and Cretinism**.

### Final Answer:
The mismatched pair is **Hypercortisolism and Cretinism**.