Cause of Addison's disease is

Options

A. Hyposecretion of aldosterone hormone
B. Hypersecretion of aldosterone hormone
C. Hyposecretion of cortisone hormone
D. Hypersecretion of cortisone hormone

Explanation

### Step-by-Step Solution:

1. **Understanding Addison's Disease**:
Addison's disease is a condition that occurs when the adrenal glands do not produce enough hormones. The primary hormones affected are glucocorticoids (like cortisol) and mineralocorticoids (like aldosterone).

2. **Hormonal Deficiency**:
The disease is characterized by hyposecretion, which means there is a lower-than-normal production of these hormones. This deficiency leads to various symptoms, including fatigue, weight loss, low blood pressure, and changes in skin pigmentation.

3. **Autoimmune Component**:
One of the main causes of Addison's disease is an autoimmune disorder. In this case, the body's immune system mistakenly attacks the adrenal cortex, which is the outer layer of the adrenal glands responsible for hormone production.

4. **Role of Antibodies**:
The immune system produces antibodies that target and destroy the adrenal cortex. This destruction impairs the gland's ability to produce the necessary hormones, leading to the symptoms associated with Addison's disease.

5. **ACTH Binding**:
The condition can also involve the binding of ACTH (Adrenocorticotropic Hormone), which is produced by the pituitary gland. In Addison's disease, despite high levels of ACTH, the adrenal glands are unable to respond adequately due to their impaired function.

6. **Conclusion**:
Therefore, the primary cause of Addison's disease is the hyposecretion of glucocorticoids and aldosterone due to autoimmune destruction of the adrenal cortex.

### Final Answer:
The cause of Addison's disease is the hyposecretion of glucocorticoids and aldosterone due to autoimmune destruction of the adrenal cortex.

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