Match the columns I,II and III and find correct options

Options

A. (A - ii - S) (B - iii - R) (C - i - Q) (D - iv - P)
B. (A - iv - P) (B - i - Q) (C - ii - R) (D - iii - S)
C. (A - iv - P) (B - iii - R) (C - i - S) (D - ii - R)
D. (A - iii - R) (B - i - Q) (C - iv - P) (D - ii - S)

Answer

B

Explanation

Sickle cell anaemia – It is due to the point mutation in a gene code for hemoglobin result in change in amino acid from valine to glutamic acid.
Inheritance in sickle cell anaemia :
`Hb^A Hb^A `- Normal
`Hb^A Hb^S` - Carrier
`Hb^S Hb^S `- Affected
Phenylketonuria : It is an autosomal recessive disease. It is caused due to lack of enzyme phenlalanine hydroxylose responsible to transform phenylalanine into tyrosine.
Phenylalanine `underset("Hydroxylase")overset("Phenylalanine")to `Tyrosine
Alkaptonuria : Alkaptonuria (black urine disease) is a rare inherited genetic disorder in which the body cannot process the amino acids phenylalanine and tyrosine. Thalassemia : Thalessemia cell inherited blood disorder characterized by abnormal haemoglobin production.