Select the correct match

Options

A. Haemophilia–Y linked
B. Phenylketonuria – Autosomal dominant trait
C. Sickle cell anaemia – Autosomal recessive trait, chromosome-11
D. Thalassemia – X linked

Explanation

To solve the question "Select the correct match," we need to analyze each option provided and determine if the genetic condition is correctly matched with its inheritance pattern. Here’s a step-by-step solution:

### Step 1: Analyze Hemophilia
- **Condition**: Hemophilia
- **Inheritance Pattern**: Y-linked (incorrect)
- **Correct Information**: Hemophilia is an X-linked recessive disorder, meaning the gene responsible for hemophilia is located on the X chromosome. Males are more affected due to having only one X chromosome.

**Hint for Step 1**: Remember that hemophilia is related to the X chromosome, not the Y chromosome.

### Step 2: Analyze Phenylketonuria (PKU)
- **Condition**: Phenylketonuria
- **Inheritance Pattern**: Autosomal dominant (incorrect)
- **Correct Information**: PKU is an autosomal recessive disorder. It occurs when there is a deficiency in the enzyme phenylalanine hydroxylase, leading to the accumulation of phenylalanine in the body.

**Hint for Step 2**: Recall that PKU is inherited in an autosomal recessive manner, requiring two copies of the mutated gene for the disorder to manifest.

### Step 3: Analyze Sickle Cell Anemia
- **Condition**: Sickle Cell Anemia
- **Inheritance Pattern**: Autosomal recessive trait (correct)
- **Correct Information**: Sickle cell anemia is indeed an autosomal recessive disorder caused by a mutation in the hemoglobin gene located on chromosome 11. Individuals need two copies of the mutated gene to express the disease.

**Hint for Step 3**: Sickle cell anemia is a classic example of an autosomal recessive disorder; think about how it affects hemoglobin structure.

### Step 4: Analyze Thalassemia
- **Condition**: Thalassemia
- **Inheritance Pattern**: X-linked (incorrect)
- **Correct Information**: Thalassemia is an autosomal recessive disorder, not X-linked. It involves mutations in the genes responsible for hemoglobin production, leading to reduced hemoglobin levels.

**Hint for Step 4**: Remember that thalassemia is also an autosomal disorder, similar to sickle cell anemia.

### Conclusion
After analyzing all the options, the only correct match is:
- **Sickle Cell Anemia** with **Autosomal Recessive Trait** on **Chromosome 11**.

### Final Answer
The correct match is: **Sickle Cell Anemia - Autosomal Recessive Trait on Chromosome 11**.