DNA is a polymer of nucleotides which are linked to each other by `3'-5'` phosphodiester bond . To prevent polymerisation of nucleotides, which of the following modifications would you choose ?

Options

A. Replace purine with pyrimidines
B. Remove/replace 3’ OH group in deoxyribose
C. Remove/replace 2’ OH group with some other group in deoxyribose
D. Both ‘b’ and ‘c’

Answer

B

Explanation

The successive nucleotides are joined by 3. – 5. phosphodiester bonds.
To prevent polymerization of nucleotide replace OH.3 group in deoxyribose