The relative reactivities of acyl compound towards nucleophilic substitution are in the order of

Options

A. Acid anhydride gt Amide gt Ester gt Acyl chloride
B. Acyl chloride gt Ester gt Acid anhydride gt Amide
C. Acyl chloride gt Acid anhydride gt Ester gt Amide
D. Ester gt Acyl chloride gt Amide gt Acid anhydride

Answer

C

Explanation

Better is the leaving group, higher will be the reactivity of acyl compounds towards nucleophilic acyl substitution. Weaker bases are better leaving group and they are derived from strong acids.
Decreasing strength of alkanoyl or acyl compounds
`HCl gt R - COOH gt R - CO - OR gt R -CO - NH_2`
Decreasing leaving ability or increasing basic character.
`Cl^(-) gt R - underset(O)underset(||)C - O^(-) gt R - O^(-) gt overlineNH_2` .