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A : Sickel cell anemia occurs due to the...

A : Sickel cell anemia occurs due to the point mutation.
R : mRNA produced from `Hb(s)` gene has GAG instead of GUG.

A

If both Assertion & Reason are true and the reason is the correct explanation of the assertion, then mark (1)

B

If both Assertion & Reason are true and the reason is not the correct explanation of the assertion , then mark (2)

C

If Assertion is true statement but Reason is false, then mark (3)

D

If both Assertion and Reason are false statements, then mark (4)

Text Solution

Verified by Experts

The correct Answer is:
C
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Sickel cell anemia is the result of ________ mutation in the haemoglobin gene

Assertion (A): Sickle cell anaemia is an example of point mutation. Reason ( R): It is caused by addition or deletion of nitrogenous bases in the DNA or mRNA.

Assertion: Hb^(S) Hb^(S) is homozygous condition of sickle cell anaemia. Reason: It occurs due to substitution of glutamic acid by valine at sixth position in beta -chain of haemoglobin.

Given below are assertion and reason. Point out if both are true with reason being correct explanation (A), both are true but reason is not correct explanation (B), assertion is true but reason is wrong ( C) and both are wrong (D). Assertion. Hb^(s)Hb^(s) is homozygous condition of sickle cell anaemia. Reason. It occurs due to substitution of glutamic acid by valine at sixth position in beta -chain of haemoglobin.

Assertion :-Sickle-cell anaemia is caused by the substitutin of glutamic acid by valine at the sixth position of the beat globin chain of the hemoglobin moecule. Reason :- It is due to the single base substatution at the sixth codon of the beta lobin gene from GUG to GAG.

Sickle - cell anemia trait is adaptation against malaria. It is due to substitution ( point mutation ) in which

Sickle cell anemia is a genetic disorder where the body produces an abnormal hemoglobin called hemoglobin S. Red blood cells are normally flexible and round, but when the hemoglobin is defective, blood cells take on a “sickle” or crescent shape. Sickle cell anemia is caused by mutations in a gene called HBB. It is an inherited blood disorder that occurs if both the maternal and paternal copies of the HBB gene are defective. In other words, if an individual receives just one copy of the defective HBB gene, either from mother or father, then the individual has no sickle cell anemia but has what is called “sickle cell trait”. People with sickle cell trait usually do not have any symptoms or problems but they can pass the mutated gene onto their children. There are three inheritance scenarios that can lead to a child having sickle cell anemia: - Both parents have sickle cell trait - One parent has sickle cell anemia and the other has sickle cell trait - Both parents have sickle cell anemia If one parent has sickle cell anemia and the other has sickle cell trait, there is __________that their children will have sickle cell anemia and ___________will have sickle cell trait.

Sickle cell anemia is a genetic disorder where the body produces an abnormal hemoglobin called hemoglobin S. Red blood cells are normally flexible and round, but when the hemoglobin is defective, blood cells take on a “sickle” or crescent shape. Sickle cell anemia is caused by mutations in a gene called HBB. It is an inherited blood disorder that occurs if both the maternal and paternal copies of the HBB gene are defective. In other words, if an individual receives just one copy of the defective HBB gene, either from mother or father, then the individual has no sickle cell anemia but has what is called “sickle cell trait”. People with sickle cell trait usually do not have any symptoms or problems but they can pass the mutated gene onto their children. There are three inheritance scenarios that can lead to a child having sickle cell anemia: - Both parents have sickle cell trait - One parent has sickle cell anemia and the other has sickle cell trait - Both parents have sickle cell anemia If both parents have sickle cell trait, then there is _______________of the child having sickle cell anemia.

Sickle cell anemia is a genetic disorder where the body produces an abnormal hemoglobin called hemoglobin S. Red blood cells are normally flexible and round, but when the hemoglobin is defective, blood cells take on a “sickle” or crescent shape. Sickle cell anemia is caused by mutations in a gene called HBB. It is an inherited blood disorder that occurs if both the maternal and paternal copies of the HBB gene are defective. In other words, if an individual receives just one copy of the defective HBB gene, either from mother or father, then the individual has no sickle cell anemia but has what is called “sickle cell trait”. People with sickle cell trait usually do not have any symptoms or problems but they can pass the mutated gene onto their children. There are three inheritance scenarios that can lead to a child having sickle cell anemia: - Both parents have sickle cell trait - One parent has sickle cell anemia and the other has sickle cell trait - Both parents have sickle cell anemia Sickle cell anemia is a/ an ______________________ disease.

Sickle cell anemia is a genetic disorder where the body produces an abnormal hemoglobin called hemoglobin S. Red blood cells are normally flexible and round, but when the hemoglobin is defective, blood cells take on a “sickle” or crescent shape. Sickle cell anemia is caused by mutations in a gene called HBB. It is an inherited blood disorder that occurs if both the maternal and paternal copies of the HBB gene are defective. In other words, if an individual receives just one copy of the defective HBB gene, either from mother or father, then the individual has no sickle cell anemia but has what is called “sickle cell trait”. People with sickle cell trait usually do not have any symptoms or problems but they can pass the mutated gene onto their children. There are three inheritance scenarios that can lead to a child having sickle cell anemia: - Both parents have sickle cell trait - One parent has sickle cell anemia and the other has sickle cell trait - Both parents have sickle cell anemia If both parents have sickle cell trait, then there is _______________of the child having sickle cell trait.

AAKASH INSTITUTE-PRINCIPLES OF INHERITANCE AND VARIATION-Assignment (SECTION-D) Assertion-Reason Type Questions
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  2. A : Sickel cell anemia occurs due to the point mutation. R : mRNA pr...

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  3. A : Holandric traits are passed from one generation to the next genera...

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  4. Assertion: Dominance is not an autonomous feature of a gene or the pro...

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  5. A : The possibility of a female becoming a haemophilic is extremely ra...

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  6. A : Polyploids with odd number of chromosomes are prepagated vegetativ...

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  7. A : The hetrozygotic female for haemophilia may transmit the disease t...

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  8. A : Non-allosomic genic determination of sex is found in bacteria. R...

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  9. A : Non-allosomic genic determination of sex is found in bacteria. R...

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  10. A : Crossing over is exchange of genetic material between non-homologo...

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  11. A : Mendel gave postulates like "principles of segregation and princip...

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  12. A : Test cross is the tool for knowing linkage between genes. R : Mo...

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  13. A : Myotonic dystrophy is is caused by recessive mutant pleiotropic ge...

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  14. A : In snapdragon, F(1) plants do not have red or white flowers. R ...

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  15. A : en block inheritance of all genes located on the same chromosome m...

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  16. A : Morgan's cross III was eonducted in Drosophila to locate genes on ...

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  17. A : Antlers in male deer are sex influenced traits. R : These are co...

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  18. A : One drum stick nucleus is present in the neutrophil of normal fema...

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  19. A : Blood group phenotype is controlled by presence or absence of anti...

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  20. A : XO type sex determination is found in large number of insects. ...

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