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Attack by a strong nucleophile such ...

Attack by a strong nucleophile such as `CH_(3)O^(Theta)` (Methoxide ion ) on an epoxide occurs at the least hindered carbon similar to an `S_(N)2` reaction

Attack by a weak nucleophile such as MeOH . Can occur only when the epoxide has been protonated so that a better leaving group is formed under acidic condition weak nucleophile attacks more substituted carbon to give final product .
Given synthetic transformation can be performed by

A

`CH_(3)-overset(O)overset(||)(C )- OOH //H_(2)O`

B

`(i) OsO_(4) (ii) " Hydrolysis "`

C

`(i) KMnO_(4), overset(Theta)(O ) H , 0^(@)C` (ii) Hydrolysis

D

`(i)Br_(2) // H_(2) O (ii) overset(Theta) (O) H`

Text Solution

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The correct Answer is:
A

NA
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Attack by a strong nucleophile such as CH_(3)O^(Theta) (Methoxide ion ) on an epoxide occurs at the least hindered carbon similar to an S_(N)2 reaction Attack by a weak nucleophile such as MeOH . Can occur only when the epoxide has been protonated so that a better leaving group is formed under acidic condition weak nucleophile attacks more substituted carbon to give final product . Which statement is true about base ring opening reaction of epoxide ?

Attack by a strong nucleophile such as CH_(3)O^(Theta) (Methoxide ion ) on an epoxide occurs at the least hindered carbon similar to an S_(N)2 reaction Attack by a weak nucleophile such as MeOH . Can occur only when the epoxide has been protonated so that a better leaving group is formed under acidic condition weak nucleophile attacks more substituted carbon to give final product . What would be the major product of the given transformation ?

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