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Attack by a strong nucleophile such ...

Attack by a strong nucleophile such as `CH_(3)O^(Theta)` (Methoxide ion ) on an epoxide occurs at the least hindered carbon similar to an `S_(N)2` reaction

Attack by a weak nucleophile such as MeOH . Can occur only when the epoxide has been protonated so that a better leaving group is formed under acidic condition weak nucleophile attacks more substituted carbon to give final product .
What would be the major product of the given transformation ?

A

B

C

D

Text Solution

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The correct Answer is:
C
NA
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Attack by a strong nucleophile such as CH_(3)O^(Theta) (Methoxide ion ) on an epoxide occurs at the least hindered carbon similar to an S_(N)2 reaction Attack by a weak nucleophile such as MeOH . Can occur only when the epoxide has been protonated so that a better leaving group is formed under acidic condition weak nucleophile attacks more substituted carbon to give final product . Which statement is true about base ring opening reaction of epoxide ?

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