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In sickle cell anaemia, the substitution...

In sickle cell anaemia, the substitution of amino acid in the globin protein results due to

A

Single base substitution

B

polymerisation

C

Aberration in chromosome number

D

Aberration in the number of amino acids

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The correct Answer is:
A
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Read the following paragraph carefully and find out the correct words for all the three blanks indicated as (A) (B) and (C ) "the substitution of amino acid in the globin protein results due to the single base subsitution at the 6^(th) codon of the beta -globin gene from overset((A))("_____") to overset((B))("_____") . The mutant haemoglobin molecule undergoes polymerisation under overset((C))("_____") tension causing the change in the shape of the RBO from biconcave disc to elongated sickle-like structure.

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ARIHANT NEET-CHROMOSOMAL BASIS OF INHERITANCE-Chapter Exercises A Taking it together (Assorted Questions of the Chapter for Advanced level Practice )
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  2. Dominant mutations are easier to detect than recessive mutations becau...

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  4. Gynandromorphism in certain flies is the result of :

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  9. Choose the incorrect match

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  12. Which statement about genetic mutations is false?

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  13. Which of the following mutations is likely to cause the greatest impac...

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  14. Aneuploidy is a term used where

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  15. Which of the following changes to a DNA molecule is least likely to re...

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  16. The reason why some mutations which are harmful do not get eliminated ...

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  17. Application of colchicine to a vegetative bud of a homozygous tall dip...

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  18. Microorganisms have been very useful in elucidating different effects ...

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  19. Which of the following organisms is known as an allopolyploidy?

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  20. One of the reasons why haploids are considered more suitable than dipl...

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