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A couple both carriers of sickle cell an...

A couple both carriers of sickle cell anaemia planning to get married, wants to know the chances of having anaemic progeny

A

1

B

0.75

C

0.5

D

0.25

Text Solution

Verified by Experts

The correct Answer is:
D
It is clear from the condition given that the parents are carrier of the disease Sickle-cell anaemia is an autosomal linked recessive trait which gets transmited from parents to offspring, When both the partners are carrier for gene. According to the situation given in the question the cross is given below
Thus the chances of getting anaemic progeny is only 25% i.e daughter will only be affected
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Sickle cell anemia is a genetic disorder where the body produces an abnormal hemoglobin called hemoglobin S. Red blood cells are normally flexible and round, but when the hemoglobin is defective, blood cells take on a “sickle” or crescent shape. Sickle cell anemia is caused by mutations in a gene called HBB. It is an inherited blood disorder that occurs if both the maternal and paternal copies of the HBB gene are defective. In other words, if an individual receives just one copy of the defective HBB gene, either from mother or father, then the individual has no sickle cell anemia but has what is called “sickle cell trait”. People with sickle cell trait usually do not have any symptoms or problems but they can pass the mutated gene onto their children. There are three inheritance scenarios that can lead to a child having sickle cell anemia: - Both parents have sickle cell trait - One parent has sickle cell anemia and the other has sickle cell trait - Both parents have sickle cell anemia If one parent has sickle cell anemia and the other has sickle cell trait, there is __________that their children will have sickle cell anemia and ___________will have sickle cell trait.

Sickle cell anemia is a genetic disorder where the body produces an abnormal hemoglobin called hemoglobin S. Red blood cells are normally flexible and round, but when the hemoglobin is defective, blood cells take on a “sickle” or crescent shape. Sickle cell anemia is caused by mutations in a gene called HBB. It is an inherited blood disorder that occurs if both the maternal and paternal copies of the HBB gene are defective. In other words, if an individual receives just one copy of the defective HBB gene, either from mother or father, then the individual has no sickle cell anemia but has what is called “sickle cell trait”. People with sickle cell trait usually do not have any symptoms or problems but they can pass the mutated gene onto their children. There are three inheritance scenarios that can lead to a child having sickle cell anemia: - Both parents have sickle cell trait - One parent has sickle cell anemia and the other has sickle cell trait - Both parents have sickle cell anemia If both parents have sickle cell trait, then there is _______________of the child having sickle cell trait.

Write the genotype of (i) an individual who is carrier of sickle cell anaemia gene but apparently unaffected, and (ii) an individual affected with the disease.

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ARIHANT NEET-HUMAN GENETICS-Chapter Exercise (c) Medical entrances gallery (Collection of questions asked in NEET & Various Medical Entrance Exams)
  1. A human female with turner's syndrome

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  2. A man whose father was colourblind marries a woman, who had a colourbl...

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  3. A couple both carriers of sickle cell anaemia planning to get married,...

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  4. Which of the following is correctly matched?

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  5. A person affected with phenylketonuria lacks an enzyme that converts t...

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  6. In sickle cell anaemia, the sequence of amino acid from first to seven...

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  7. Anish is having colour blindness and married to Sheela, who is not col...

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  8. The genotype of a person suffering from Klinefelter's symdrome is

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  9. In alpha thalasssemia the gene HBAI is located on chromosome

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  10. Sickle-cell anaemia is caused due to the substitution of :

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  11. Down's syndrome is an example

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  12. In down's syndrome (Mongolism), each cell has how many chromosomes?

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  13. In the given pedigree, the shaded individuals are homozygous recessive...

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  14. Haemophilia is related to

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  15. The gene of sickle cell anaemia is inherited by

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  16. Represented below is the inheritance pattern of a certain type of trai...

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  17. A normal - visioned man whose father was colourblind. Theiy have their...

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  18. A woman with albinic father marries an albinic man. The proportion of ...

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  19. Which following pair of diseases is caused by two genes located on hum...

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  20. If father shown normal gentype and mother shown a carrier trait for ha...

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