Select the option which is not correct with respect to enzyme action

Options

A. Malonate is a competitive inhibtior of succines dehydrogenase
B. Substrate binds with enzyme at its active site
C. Addition of lot of succinate does not reverse the inhibition of succinic dehydrogenase by malonate
D. A non-competitve inhibitor binds the enzyme at a site distinct form that which binds the substrate.

Answer

C

Explanation

Inhibition of succine dehydrogen by malonate is an example of competitive inhibition, where malonate occupies the active site of the enzyme and blocks it . However this kind of inhibition is reversible and increase in substrate concentration wil reverse this inhibtion . In non-competitive inhibition the inhibitor binds to the enzyme at a site different form its substrate binding site (i.e., the active site).