Select the option which is not correct with respect to enzyme action

Options

A. Malonate is a competitive inhibitor of succinic dehydrogenase
B. Substrate binds with enzyme at its ac- tive site
C. Addition of lot of succinate does not re- verse the inhibition of succinic dehydro- genase by malonate
D. A non-competitive inhibitor binds the enzyme at a site distinct from that which binds the substrate

Explanation

Inhibition of succinate dehydrogenase by malonate is an example of competitive inhibition , where malonate occupies the active site fo the enzyme and blocks it .Howere , this kind of inhibition is reversible and increase in substrate concentration will reverse the inhibition .In non-competitive inhibition the inhibitor binds to the enzyme at a site different form its substrate (i,e the active site ).