The complex used as an anticancer agent is

Options

A. `mer-[Co(NH_(3))_(3)CI_(3)]`
B. `cis-[Pt(NH_(3))_(2)CI_(2)]`
C. `cis-K_(2)[PtBr_(2)CI_(2)]`
D. `Na-(2)[CoCI_(4)]`

Answer

B

Explanation

A very important medical use of `Pt(+2)` compounds is the use of cis isomer of `[Pt(NH_(3))_(2)C1_(2)]` as an anti-canceer drug for treating several types of malignant tumours. The trans isor is ineffective. The cis isomer is called cisplatin and is highly toxic. It is injected into the bloodstream and the more reactive C1 group (ligands) bond to a N atom in guanosine (part of the DNA molecule). The cisplatin can bond to two different guanosine units and by bridging between them it upsets the normal reproduction of DNA. Those cell which are undergoing cell division are attacked by cisplatin. Tumours usually growing rapidly, but so also are the bone marrow cells (producing red and white blood cells) and cell in the testes (producing sperms), so these are also affected. Dramatic results are possible, and a large number of patients are completely cured. There is a critical balance between giving enough cisplatin to kill the tumour and leaving sufficient white blood cells to protect the body from attack by bacteria and viruses.