Which will not give acetamide on reaction with ammonia

Options

A. Acetic acid
B. Acetyl chloride
C. Acetic anhydride
D. Methyl formate

Answer

To determine which compound will not give acetamide upon reaction with ammonia, we will analyze each option provided.

### Step-by-Step Solution:

1. **Understanding Acetamide**:
- Acetamide has the structure CH3C(=O)NH2. It is formed when an acyl compound reacts with ammonia.

2. **Analyzing Each Option**:
- **Option 1: Acetic Acid (CH3COOH)**:
- Acetic acid can react with ammonia (NH3) to form ammonium acetate initially. However, upon heating, it can dehydrate to form acetamide (CH3C(=O)NH2).
- **Conclusion**: Acetic acid can give acetamide.

- **Option 2: Acetyl Chloride (CH3COCl)**:
- Acetyl chloride reacts with ammonia to form acetamide directly. The reaction involves nucleophilic attack by ammonia on the carbonyl carbon, leading to the formation of acetamide.
- **Conclusion**: Acetyl chloride can give acetamide.

- **Option 3: Acetic Anhydride (CH3CO)2O**:
- Acetic anhydride also reacts with ammonia to produce acetamide. The mechanism is similar to that of acetyl chloride where ammonia attacks the carbonyl carbon.
- **Conclusion**: Acetic anhydride can give acetamide.

- **Option 4: Methyl Formate (HCOOCH3)**:
- Methyl formate is an ester. When it reacts with ammonia, it does not form an amide. Instead, it typically undergoes hydrolysis or transesterification, but not direct formation of an amide.
- **Conclusion**: Methyl formate does not give acetamide.

3. **Final Answer**:
- The compound that will not give acetamide upon reaction with ammonia is **Methyl Formate**.