The changes of Karyokinesis in mitosis occur in:-

Options

A. Cytoplasm
B. Nucleus
C. Both 1 and 2
D. Nucleolus

Answer

### Step-by-Step Solution:

1. **Understanding Karyokinesis**:
- Karyokinesis is the process of nuclear division that occurs during mitosis and meiosis. It involves the separation of the cell's nucleus into two daughter nuclei.

2. **Identifying the Changes**:
- During karyokinesis, significant changes occur within the nucleus as it prepares for division. This includes the replication and segregation of DNA, as well as changes in nuclear proteins.

3. **Considering Cytokinesis**:
- After karyokinesis, cytokinesis follows, which is the division of the cytoplasm. This means that changes in karyokinesis will ultimately lead to changes in the cytoplasm as well.

4. **Analyzing the Options**:
- **Option 1: Cytoplasm** - This option is correct because changes in karyokinesis will also affect the cytoplasm during cytokinesis.
- **Option 2: Nucleus** - This option is incorrect because karyokinesis specifically refers to the division of the nucleus itself.
- **Option 3: Both 1 and 2** - This option is misleading because while karyokinesis affects the nucleus, it does not imply that both options are correct in the context of karyokinesis changes.
- **Option 4: Nucleolus** - This option is incorrect as the nucleolus is involved in ribosomal RNA synthesis and is not directly related to karyokinesis.

5. **Conclusion**:
- The correct answer is that the changes of karyokinesis in mitosis occur in the **Cytoplasm** and the **Nucleus**, but since the question specifically asks about karyokinesis, the most relevant answer is **Cytoplasm**.

### Final Answer:
The changes of karyokinesis in mitosis occur in the **Cytoplasm** and the **Nucleus**.