Group of hormones which is related with cytoplasmic bounded receptors ?

Options

A. Hypothalamic hormones and epinephrine
B. Thyroid hormone and estradiol
C. Insulin and glucagon
D. GH and MSH

Answer

To answer the question regarding which group of hormones is related to cytoplasmic bounded receptors, we can follow these steps:

### Step-by-Step Solution:

1. **Understand the Concept of Cytoplasmic Bounded Receptors**:
- Cytoplasmic bounded receptors are typically associated with steroid hormones and thyroid hormones. These receptors are located in the cytoplasm of the cell and bind to hormones that can easily pass through the cell membrane.

2. **Evaluate the Given Options**:
- **Option 1: Hypothalamic Hormones and Epinephrine**:
- Hypothalamic hormones are generally peptide hormones and do not bind to cytoplasmic receptors. Epinephrine (adrenaline) is a catecholamine that binds to membrane-bound receptors, not cytoplasmic ones.
- **Conclusion**: This option is incorrect.

- **Option 2: Thyroid Hormone and Estradiol**:
- Thyroid hormones (like thyroxine) and estradiol (a steroid hormone) both bind to cytoplasmic receptors. Thyroid hormones can enter the cell and bind to receptors in the cytoplasm, while estradiol also binds to cytoplasmic receptors before influencing gene expression.
- **Conclusion**: This option is correct.

- **Option 3: Insulin and Glucagon**:
- Insulin and glucagon are peptide hormones that bind to receptors on the cell membrane, not cytoplasmic receptors.
- **Conclusion**: This option is incorrect.

- **Option 4: Growth Hormone and Melanocyte Stimulating Hormone**:
- Both of these hormones are also peptide hormones that bind to membrane receptors and do not interact with cytoplasmic receptors.
- **Conclusion**: This option is incorrect.

3. **Final Answer**:
- Based on the evaluations, the correct answer is **Option 2: Thyroid Hormone and Estradiol**.