Point mutation involves :

Options

A. insertion
B. change in single base pair
C. duplication
D. deletion

Answer

### Step-by-Step Text Solution:

1. **Understanding Point Mutation**: Point mutation is a type of mutation that involves a change in a single nucleotide base pair in the DNA sequence.

2. **Analyzing the Options**:
- **Option 1: Insertion**: This option suggests that point mutation involves insertion. This is incorrect because insertion refers to the addition of one or more nucleotide bases, which is not characteristic of point mutations.
- **Option 2: Change in Single Base Pair**: This option states that point mutation involves a change in a single base pair. This is correct because point mutations specifically refer to alterations at a single nucleotide position.
- **Option 3: Duplication**: This option suggests that duplication is involved in point mutation. This is incorrect because duplication can involve multiple base pairs and is not limited to a single point.
- **Option 4: Deletion**: This option suggests that deletion is involved in point mutation. This is also incorrect as deletion typically refers to the removal of one or more nucleotide bases, which can also extend beyond a single base.

3. **Conclusion**: Based on the analysis of the options, the correct answer is **Option 2: Change in Single Base Pair**. An example of point mutation is sickle cell anemia, where a single nucleotide change leads to a significant effect on the phenotype.