Aspirin is obtained by the reaction of salicylic acid with :

Options

A. Acetone
B. Acetaldehyde
C. Acetyl chloride
D. Acetamide

Answer

To determine how aspirin is obtained from salicylic acid, we need to understand the reaction involved. Here’s a step-by-step solution:

### Step 1: Identify the Reactants
Aspirin is synthesized from salicylic acid. The other reactant required for this synthesis is acetic anhydride or acetyl chloride.

**Hint:** Look for a reagent that can introduce an acetyl group (−COCH₃) to the salicylic acid.

### Step 2: Understand the Structure of Salicylic Acid
Salicylic acid is 2-hydroxybenzoic acid, which has a hydroxyl group (−OH) and a carboxylic acid group (−COOH) on the benzene ring.

**Hint:** Familiarize yourself with the structure of salicylic acid to understand where the reaction will occur.

### Step 3: Reaction Mechanism
The reaction between salicylic acid and acetic anhydride (or acetyl chloride) involves the hydroxyl group of salicylic acid attacking the carbonyl carbon of the acetic anhydride or acetyl chloride. This results in the formation of an ester bond.

**Hint:** Remember that this type of reaction is known as esterification, where an alcohol reacts with an acid to form an ester.

### Step 4: Formation of Aspirin
When salicylic acid reacts with acetic anhydride, the hydroxyl group (−OH) of salicylic acid is replaced by the acetyl group (−OCOCH₃), resulting in the formation of aspirin (acetylsalicylic acid).

**Hint:** The product will retain the carboxylic acid group from salicylic acid, while the hydroxyl group is converted into an ester.

### Step 5: Write the Chemical Equation
The chemical equation for the reaction can be represented as follows:

\[ \text{Salicylic Acid} + \text{Acetic Anhydride} \rightarrow \text{Aspirin} + \text{Acetic Acid} \]

**Hint:** Ensure to balance the equation by including all reactants and products.

### Conclusion
Aspirin is obtained by the reaction of salicylic acid with acetic anhydride (or acetyl chloride).

**Final Answer:** Aspirin is obtained by the reaction of salicylic acid with acetic anhydride (or acetyl chloride).

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